Fish oil (FO) and phytocannabinoids have received considerable attention for their intestinal anti-inflammatory effects. We investigated whether the combination of FO with cannabigerol (CBG) and cannabidiol (CBD) or a combination of all three treatments results in a more pronounced intestinal antiin … Cannabidiol (CBD) is a powerful supplement with anti-inflammatory properties and has been proven to have the ability to help control difficult-to-manage symptoms and help treat several previously untreatable conditions. Among other things, CBD oil can help to fight cancer and irritable bowel diseases, improve schizophr Did you know there is a special relationship between CBD oil and omega fatty acids, or more specifically, omega-3 fatty acids? Learn more…
Efficacy of combined therapy with fish oil and phytocannabinoids in murine intestinal inflammation
Fish oil (FO) and phytocannabinoids have received considerable attention for their intestinal anti-inflammatory effects. We investigated whether the combination of FO with cannabigerol (CBG) and cannabidiol (CBD) or a combination of all three treatments results in a more pronounced intestinal antiinflammatory action compared to the effects achieved separately. Colitis was induced in mice by 2,4-dinitrobenzenesulfonic acid (DNBS). CBD and CBG levels were detected and quantified by liquid chromatography coupled with time of flight mass spectrometry and ion trap mass spectrometry (LC-MS-IT-TOF). Endocannabinoids and related mediators were assessed by LC-MS. DNBS increased colon weight/colon length ratio, myeloperoxidase activity, interleukin-1β, and intestinal permeability. CBG, but not CBD, given by oral gavage, ameliorated DNBS-induced colonic inflammation. FO pretreatment (at the inactive dose) increased the antiinflammatory action of CBG and rendered oral CBD effective while reducing endocannabinoid levels. Furthermore, the combination of FO, CBD, and a per se inactive dose of CBG resulted in intestinal anti-inflammatory effects. Finally, FO did not alter phytocannabinoid levels in the serum and in the colon. By highlighting the apparent additivity between phytocannabinoids and FO, our preclinical data support a novel strategy of combining these substances for the potential development of a treatment of inflammatory bowel disease.
Keywords: cannabidiol; cannabigerol; fish oil; inflammatory bowel disease; phytocannabinoids.
© 2020 John Wiley & Sons Ltd.
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Why CBD & Omega-3?
Cannabidiol (CBD) is a powerful supplement with anti-inflammatory properties and has been proven to have the ability to help control difficult-to-manage symptoms and help treat several previously untreatable conditions. Among other things, CBD oil can help to fight cancer and irritable bowel diseases, improve schizophrenia symptoms, relieve anxiety, and enhance the quality of sleep.
Of all the benefits offered by CBD, natural pain relief tops the list for many. Evidence suggests that cannabinoids may prove useful in pain modulation by inhibiting neuronal transmission in pain pathways. Some studies, including an investigation published in the Journal of Experimental Medicine, found that CBD significantly reduces inflammation in mice and rats – but it’s not only rodents that experience these effects. A 2008 review identified that CBD offered effective pain relief without inducing adverse side effects in patients.
One of the most important health benefits of CBD oil is its analgesic (pain relieving) effects. It’s thought that CBD interacts with receptors in the brain and immune system to reduce inflammation and alleviate pain.
Seizures occur when there’s a dramatic fluctuation of electrical activity in the brain. Over the years, several high profile cases have raised awareness of CBD’s anti-seizure properties, but it’s only recently that science has been able to confirm this link.
While CBD is most commonly used to treat physiological symptoms, there’s a growing body of research that indicates it can also be useful as part of the treatment regimens for a range of mental health conditions, including anxiety.
Research indicates that CBD may be valuable in the treatment of cancer in many different ways. CBD, in addition to some of the other compounds found in cannabis, has an antitumor effect and can amplify the death of tumor cells in both colon cancer and leukemia.
Reduces the risk for Diabetes
CBD oil may reduce the risk of developing Diabetes. In a recent study, researchers set out to explore what effect CBD would have on non-obese, diabetes-prone female mice. Only 32 percent of the mice that received the CBD were diagnosed with Diabetes, compared to 100 percent of the untreated group.
CBD + Omega-3
CBD oil works by interacting with the body’s endocannabinoid system (ECS), which is a physiological system made up of neurotransmitters named endocannabinoids. These chemical messengers bind to and activate cannabinoid receptors, which triggers a multitude of critical physiological responses involved in the regulation of inflammation, pain, fertility, appetite, memory, and mood, among other biological processes. The cannabinoids present in CBD oil are also able to activate these cannabinoid receptors – and therefore, like our bodies’ own endocannabinoids, are able to exert positive effects on our health and wellbeing.
So Why Omega-3 + CBD?
In order to get the most out of our CBD supplements, the phytocannabinoids require a fat source in order to reach and stimulate the endocannabinoid receptors. Consuming CBD with a high-quality omega-3 supplement will dramatically increase the effects of your CBD supplement.
Evidence also indicates that omega-3 plays a crucial role in maintaining the proper functioning of your endocannabinoid system.
Most importantly, omega-3 helps to maintain your ECS by:
- Maintaining and repairing cannabinoid receptors
- Providing the body with the ingredients necessary to grow more cannabinoid receptors
- Helping the body to synthesize endocannabinoids
- Keeping the body’s omega-6 to omega-3 ratio low, which helps to maintain healthy receptor membranes
- Aids in the conversion of one type of cannabinoid to another as needed
- Helps to metabolically regulate the ECS by creating the enzymes that produce and degrade cannabinoids
For these reasons, it is vital to note that the only way for your body to reap the full range of benefits provided by CBD is to ensure that your dietary and/or supplementary intake of omega-3 is sufficient.
Who can benefit from CBDO3?
CBDO3 combines two of the worlds most powerful natural anti-inflammatory health products. Working together these ingredients complement one another and improve one another’s efficacy simultaneously. This product is ideal for people looking to relieve, stress and anxiety, to help improve sleep and focus. CBDO3’s high potency omega-3’s will help reduce inflammation in the body all while carrying the phytocannabinoids to the endocannabinoid receptors to promote healing and wellness in the body. This product is unique in the sense that its effects can be felt nearly immediately. So if you are looking to improve your health or relieve or alleviate any condition named above this CBDO3 is the product for you.
CBD Oil and Omega-3 Fatty Acids: How They Work Together
Did you know there is a special relationship between CBD oil and omega fatty acids, or more specifically, omega-3 fatty acids? Who would have known? Apparently many experts have uncovered this association, and we’re excited to let you know about it because it could significantly change how well you respond to CBD oil (i.e., hemp oil).
CBD and Omega-3 Fatty Acids
CBD (cannabidiol) oil is derived from the leaves and flowers of hemp. This hemp oil is a type of cannabinoid, but unlike another common cannabinoid (THC, or tetrahydrocannabinol), it does not produce psychoactive effects.
Cannabidiol works on the endocannabinoid system , which is involved in many physiological functions ranging from mood and inflammation to metabolism and immune system functioning. Although the exact ways CBD oil works in the body is still under investigation, it appears to have a significant impact on mimicking the body’s own production of endocannabinoids.
Here’s where the relationship gets interesting. The body’s natural endocannabinoids (“endo” meaning the cannabinoids are produced inside the body rather than coming from outside sources) are made from the omega-3 fatty acids found in your body’s cells. Therefore, when we eat foods (e.g., nuts, fish, flaxseeds) or take in supplements that contain omega-3 essential fatty acids, the body transforms them into endocannabinoids.
Essential fatty acids have an ability to switch on special receptors in the cell membranes, which in turn cause the cells to perform certain jobs. For example, omega-3 fatty acids are involved in creating endocannabinoids and working with existing endocannabinoids to make potent anti-inflammatory substances called endocannabinoid epoxides. Omega-3 fatty acids also are important for stabilizing endocannabinoid cell membrane receptors , which allows the endocannabinoids to perform their tasks, such as energy storage and fighting inflammation.
This intimate relationship between endocannabinoids and omega-3 fatty acids illustrates how much they work together to help promote overall health. Another example of this link between CBD and omega-3 fatty acids is evidence that use of omega-3 supplements can help relieve depression, inflammation, and pain, which are the same symptoms that can be relieved when taking CBD oil.
How important are omega-3s?
If you are deficient in omega-3 fatty acids, it can have a significant impact on endocannabinoid production and the entire system and, by extension, the ability of CBD oil to be effective. Since approximately 95 percent of adults in the United States are deficient in omega-3 fatty acids, this suggests such a deficiency could have a serious impact on how well the endocannabinoid system functions.
In fact, there is evidence that a deficiency in omega-3s can cause malfunctioning of endocannabinoid receptors, which could result in increased anxiety and obesity associated with problems in the endocannabinoid system.
The bottom line
What’s the solution? To get the most from your experience using CBD oil, you should be sure to get sufficient amounts of omega-3 fatty acids. If you remain deficient in omega-3s, you most likely will not get the results you want from taking CBD oil. You can increase your intake of foods rich in omega-3 fatty acids, which include cold water fatty fish (e.g., herring, salmon, sardines, tuna), walnuts, chia seeds, or flaxseed), or take fish oil, krill oil, or algae oil.
[Editor’s Note: Barlean’s has been making fish oils for many years and recently added CBD oils to their product offering. Their emulsion process makes all of their oils highly absorbable and they come in some amazing flavors. Check out their site to learn more.]