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Acid forms of cannabinoids prevent the coronavirus spike protein from binding to human receptor sites. /PRNewswire/ — Hometown Hero CBD is pleased to announce the release of its new CBDA + CBGA Tincture. The 30ml tincture features CBDA, CBGA, CBD, and CBG at… CBD and CBG plus their acidic forms CBDA and CBGA When we think of cannabinoids, we commonly think of neutral forms like CBD and CBG . However, lately, there is some scientific data available

Hemp compounds found to fight COVID-19

Acid forms of cannabinoids prevent the coronavirus spike protein from binding to human receptor sites.

New research that is creating quite the buzz found that two compounds commonly found in hemp have the potential to combat the SARS-CoV-2 coronavirus. The compounds, cannabidiolic acid, or CBDA, and cannabigerolic acid, or CBGA, block a critical step in the process the virus uses to infect people.

No, it does not mean you can smoke weed and prevent the ’rona.

No, it does not (necessarily) mean you can squirt some CBD oil from that tincture bottle and keep the ’vid at bay. The CBDA and CBGA are not usually found in commercial hemp CBD products, but some notable companies are out there, such as Ancient Cannabis out of Oregon and Essentia Scientific from Washington state.

“CBDA and CBGG are available commercially,”said Stacy Cason at Planetarie CBDa out of Colorado, “though definitely in the minority and not in your average CBD isolate in oil product.”

“The ‘A’ forms, these are the acid forms of CBD and CBG that are generally not in most commercially available hemp products,” said Lynda LeMole, a natural products industry consultant. “The acid forms are found in the fresh plant. There are processes that stabilize the acid forms so you’d have to look at the product’s test analysis to see if the acid forms are still present in the final product.”

CBDA and CBGA naturally exist in true whole-plant hemp extracts that are not overly distilled to raise CBD content. “The data on whole plant vs CBD isolated follows the basic tenet of true botanical medicine,” said Carl Germano, vice president at Verdant Oasis. “The synergism of the whole plant performs better than isolated components from them.”

The two compounds were identified during a chemical screening by researchers at the Linus Pauling Institute at Oregon State University. The compounds bind to spike proteins found on the virus and blocked the spike protein from binding to sites in a human host, thereby preventing a step the pathogen uses to infect people.

“The acid forms are significantly under-appreciated,” said cannabis consultant Richard Rose. “Even non-stony THCA.”

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Heat inactivates the compounds and makes them unable to bind to the spike protein. That is why smoking marijuana would not work.

The researchers used the alpha and beta virus forms of the SARS-CoV-2 virus, not the latter-day delta variant nor today’s omicron variant.

But the researchers are confident these and future variants could be similarly thwarted by CBDA and CBGA.

“Regarding activity against other variants of the virus, we are hopeful that activity against the original strain and two early variants might mean activity against subsequent strains,” lead researcher Richard van Breemen, Ph.D., told Natural Products Insider. Van Breemen is professor of pharmaceutical sciences at the Linus Pauling Institute and College of Pharmacy at the Oregon State University Global Hemp Innovation Center. “That experiment, however, is yet to be done.”

Even so, the research continues the story of various natural products, like vitamin D, zinc and quercetin, that can be used as therapeutic agents against the pandemic. It also demonstrates the burgeoning possibilities into cannabinoid medicine now that the plant is being liberated from the clutches of a near-century lockdown.

“We’re just scratching the surface of what we know about cannabinoid mother and minors in the CBD family, and the positive and effective impacts it may have for preventive and therapeutic care including virus-based maladies as research is indicating,” said Thom Brodeur, CEO of Sky Wellness, a CBD brand. “There is more research to do, more ground to cover and more to discover that may—like this recent research suggests—show us use cases and value for CBD and its derivatives that have been right under our noses all this time. That’s the exciting part.”

Van Breemen concurs that the door is just being opened to hemp research.

“Hemp is a rich source of plant secondary metabolites, many of which are unique and not found in other organisms,” he said. “Already, CBD has been approved by the FDA for the treatment of some juvenile forms of epilepsy. Our findings suggest that other cannabinoids might also have medicinal properties.”

A major remaining roadblock is that coming from FDA, which gives every indication it would prefer cannabinoid medicine to be available to the public strictly through pharmaceutical drug pipelines and not through the more promiscuous dietary supplement route.

Not one week after the Oregon research was disclosed, FDA approved for use in clinical trials a CBD-based treatment for opioid use disorder. Ananda Scientific, the drug’s maker, was granted by FDA an investigational new drug (IND) designation for Nantheia ATL5.

Hometown Hero CBD launches New CBDA + CBGA Tincture Amid COVID-19 Surge

With 600mg of CBDA and 600mg of CBGA, this new hemp-derived product is legal in all 50 states and can be ordered online.

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Jan 19, 2022, 11:00 ET

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AUSTIN, Texas , Jan. 19, 2022 /PRNewswire/ — Hometown Hero CBD is pleased to announce the release of its new CBDA + CBGA Tincture. The 30ml tincture features CBDA, CBGA, CBD, and CBG at 600mg each. All the cannabinoids in tincture are hemp-derived and the product is legal in all 50 states. As with all of Hometown Hero CBD’s products, a portion of proceeds from the CBDA + CBGA Tincture will be donated to nonprofit organizations that help U.S. veterans in need.

“Hometown Hero is honored to provide a product that can help the world get through these difficult times,” said Lukas Gilkey , CEO of Hometown Hero CBD. “When we heard about their promising effects and rarity, we immediately stepped up to make sure that CBDA and CBGA would be accessible to the general public. We believe this product can have a massive positive impact.”

CBDA and CBGA recently came into the spotlight following the publication of research from Oregon State University . The two compounds only appear in greater quantities during the beginning of the plant’s life cycle. They also degrade when exposed to heat and light. Because of these factors, very few products contain substantial amounts of viable CBDA and CBGA in a consumable form.

The new CBDA + CBGA Tincture is vegan, gluten-free, and sugar-free. The tincture can provide a 30 day supply of cannabinoids when consumed at the rate of one full dropper (1ml) per day. In total, the tincture’s contents include:

  • 600mg CBDA (cannabidiolic acid)
  • 600mg CBGA (cannabigerolic acid)
  • 600mg CBD (cannabidiol)
  • 600mg CBG (cannabigerol)
  • MCT oil from organic coconuts (carrier oil)

Adults 21 and older that are curious to try Hometown Hero CBD’s products can get free samples of its hemp-derived Delta-9 THC and Delta-8 THC gummies.

In the face of the Omicron variant, Hometown Hero CBD remains dedicated to taking extensive precautions to deter COVID-19 exposure in its manufacturing processes. To learn more about Hometown Hero CBD, its full range of products, and its mission of supporting U.S. veterans, visit HometownHeroCBD.com.

About Hometown Hero CBD
Hometown Hero CBD manufactures and distributes hemp-derived Delta-9 THC, Delta-8 THC, and CBD products. Founded in 2015 by U.S. Coast Guard veteran Lukas Gilkey and Lewis Hamer , the company donates a portion of proceeds from all products sold to various charities and organizations that support veterans. For more information, visit HometownHeroCBD.com, email us at [email protected] or follow the brand on Facebook and Twitter at @HometownHeroATX and Instagram at @HometownHeroATX.

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CBD and CBG plus their acidic forms CBDA and CBGA

When we think of cannabinoids, we commonly think of neutral forms like CBD and CBG. However, lately, there is some scientific data available also on acidic forms, which are shown to have several positive impacts on the human body. Did you already hear about CBGA and CBDA?

Biosynthesis of cannabinoids

In fresh hemp, we can mostly find acidic forms of cannabinoids. Acidic forms are precursors of neutral forms, which means that neutral forms are formed from acidic forms. This process is called oxidation and occurs naturally. It can be fastened up by exposing hemp to heat and/or light.

CBGA is also known as the “mother molecule,” and all other cannabinoids are formed out of it. CBDA is synthesized from CBGA by an enzyme CBDA synthase. CBDA can further oxidize. When the process of oxidation happens, we get CBD. But not all CBGA is converted to other cannabinoids by enzymes. Sometimes oxidation process occurs to CBGA as well. In this case, we get CBG.

Potential benefits of CBDA and CBGA

We are all familiar with the benefits of the most famous cannabinoid – CBD. It is helpful to know that acidic forms of cannabinoids, like CBDA and CBGA, provide certain pharmacological activities that we can benefit from.

CBDA is supposed to have anti-inflammatory, anti-emetic, and anti-anxiety properties (Rock, 2015; Rock, 2020). Therefore, it could help reduce inflammations in our bodies, help us ease or prevent the feeling of nausea and help us cope with stress-related symptoms.

CBGA, on the other hand, is supposed to be a novel cannabinoid in the therapy of childhood epilepsy (Anderson, 2021). It is also known to have neuroprotective properties and could be a potential remedy for fighting Alzheimer’s disease (Burgaz, 2021).

Most recent discoveries

In a recently published study by van Breemen et al. (2022), CBGA and CBDA were shown to block cellular entry of the SARS-CoV-2 virus and its variants. By preventing infection of human cells by SARS-CoV-2 and preventing the entry of SARS-CoV-2 into cells, CBGA and CBDA have the potential to prevent as well as treat infection by SARS-CoV-2.

Conclusions

We are all hoping to get our pre-covid lives back. We suggest you give a combination of CBGA and CBDA a chance and try to protect yourself and your loved ones from the virus.

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